Pathologic complete response after neoadjuvant therapy of breast cancer: pitfalls and shortcomings
نویسندگان
چکیده
منابع مشابه
Prognostic significance of pathologic complete response and Ki67 expression after neoadjuvant chemotherapy in breast cancer.
BACKGROUND Recent studies have indicated that response to chemotherapy and the prognostic impact of a pathologic complete response (pCR) after neoadjuvant chemotherapy differ among breast cancer subtypes. METHODS Women with Stage I to III breast cancer treated with anthracycline and taxane-based neoadjuvant chemotherapy (four cycles of docetaxel every 3 weeks followed by four cycles of FEC ev...
متن کاملPathologic Evaluation of Breast Cancer after Neoadjuvant Therapy.
Breast cancer, one of the most common cancers in women, has various treatment modalities. Neoadjuvant therapy (NAT) has been used in many clinical trials because it is easy to evaluate the treatment response to therapeutic agents in a short time period; consequently, NAT is currently a standard treatment modality for large-sized and locally advanced breast cancers, and its use in early-stage br...
متن کاملAssociation of tumor infiltration lymphocytes and complete pathological response in breast cancer patients under neoadjuvant chemotherapy
Background: The breast cancer is the most common type of cancer in Iran. Hence determination of the optimal treatment and the contributing factors are important. The main aim in current study was to determine the association between tumor infiltration of lymphocytes (TIL) and complete pathological response in breast cancer patients after neoadjuvant chemotherapy. Methods and materials: In this...
متن کاملComparison of 5FU-base Chemoradiation with and without Eloxatin on Pathologic Complete Response in Neoadjuvant Chemoradiation of Rectal cancer
Background and Objectives: To compare pathologic complete response (pCR) in patients with advanced rectal cancer receiving neoadjuvant chemoradiotherapy (NACT) by 5-FU or Xeloda (capecitabine) with and without Eloxatin (oxaloplatin injection). Materials and Methods: Seventy-five consecutive patients with the diagnosis of advanced rectal adenocarcinoma were included. Two basic chemotherapy r...
متن کاملCancer Therapy: Clinical Relationship between Complete Pathologic Response to Neoadjuvant Chemotherapy and Survival in Triple-Negative Breast Cancer
Purpose: Pathologic complete response (pCR) to neoadjuvant chemotherapy reflects the cytotoxic efficacy of a drug, but patient survival is influenced by many other factors. The purpose of this studywas to assess the relationshipbetween increasedpCR rate and trial-level survival benefit in triple-negative breast cancer (TNBC). Experimental Design:We used bootstrap resampling from a neoadjuvant t...
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ژورنال
عنوان ژورنال: Breast Cancer Research and Treatment
سال: 2012
ISSN: 0167-6806,1573-7217
DOI: 10.1007/s10549-012-2029-1